Simulating Patient-Specific Nanoparticulate Drug Delivery for the Treatment of Vulnerable Plaques
Simulating Patient-specific Nanoparticulate Drug Delivery for the Treatment of Vulnerable Plaques – The vast majority of heart attacks occur when there is a sudden rupture of plaques, so-called vulnerable plaques, forming clots that can cause blockages in coronary arteries. The objective of the researchers’ work was to develop a computational tool-set to support the design and analysis of a catheter-based local nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. The goal is to rationally design drug-encapsulated nanoparticles in conjunction with patient-specific attributes and deliver drug locally to the diseased arteries, thereby personalizing and optimizing therapeutic intervention. To that end, a three-dimensional mathematical model of coupled transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis using the Texas Advanced Computing Center’s (TACC) HPC resources. The visualization component of this project, a 14 minute animation, seeks to explain the motivation of the research, the physical mechanism of the proposed solution concept, the mathematical models used, the computational methodology applied for simulation, and the scientific visualization of the results. Researchers Shaolie Hossain, PhD Institute for Computational Engineering and Sciences (ICES) The University of Texas at Austin Thomas JR Hughes, PhD Institute for Computational Engineering and Sciences (ICES) The University of Texas at Austin Visualization and video production Ben …
THE ANDY REID ERA
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3: Eagles drink pickle juice before game in 100-degree heat, then start with onside kick on their way to stunning 41-14 win over Cowboys at Texas Stadium. Nov. 26: McNabb rushes for 125 yards, …. 21: Reid tells Philadelphia Magazine that son Garrett …
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Top 100 Stocks Of 2012 Include Builders, Biotech, 3D
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These companies gained from new international banking rules that encouraged money center banks to sell mortgage servicing operations in order to meet higher loan loss reserve ratios and focus on traditional banking activities. With the … The Austin …
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