Louisville Drug Use: Type 2 Diabetes – New Drug to Lower Blood Cholesterol Is Being Tested

People with Type 2 diabetes often have low levels of HDL (healthy) cholesterol and high levels of triglycerides, adding to their risk for complications. A new drug to help improve cholesterol and fat levels in the blood, and to prevent heart and blood vessel disease, is being developed. Roche Pharmaceutical in Switzerland are testing this new medication called dalcetrapib.

Dalcetrapib works by inhibiting a molecule called cholesterylester transfer protein (CETP), putting it into a class of drugs called CETP inhibitors. It was developed to improve cholesterol and fat levels in the blood and to help prevent heart and blood vessel disease. Several institutions reported the results of a study conducted on dalcetrapib in the journal Diabetes, Obesity and Metabolism, August 2011. The institutions included:

Radboud University Nijmegen Medical Center in The Netherlands,
Hoffman-La Roche in Basel, Switzerland, and
the Universities of Chicago, Iowa and Washington in the USA, as well as
the Louisville Metabolic and Atherosclerosis Research Center in the USA.

People diagnosed with Type 2 diabetes, as well as people known to have the metabolic syndrome, frequently suffer from low levels of HDL (healthy) cholesterol and high levels of blood fats. Dalcetrapib was developed to increase HDL levels. Type 2 diabetics and/or people with the metabolic syndrome showed a decrease in their CETP activity of 26 to 58 per cent, and their HDL cholesterol increased by 23 to 34 per cent. LDL (unhealthy) cholesterol and similar molecules did not change. Further studies will take place to determine whether dalcetrapib can prevent heart and blood vessel disease and prolong life.

According to the American Diabetes Association, heart attacks and strokes strike people with Type 2 diabetes twice as often as people without diabetes. Arteries clogged with cholesterol are a big part of what causes heart and blood vessel disease. LDL cholesterol is the kind that clogs arteries, while HDL removes LDL from arteries. Ideally, LDL cholesterol should be less than 100 while HDL should be 60 or above.

If your cholesterol is too high, therapeutic lifestyle changes include:

a diet low in cholesterol and saturated fats,
regular exercise and weight control.

Cholesterol is found in meat and dairy products, so a vegetarian or vegan diet is a good way to begin lowering cholesterol levels. Going for a half hour walk and performing strenuous exercise for an hour three days a week, if your physician approves, can also help to lower cholesterol levels. A sensible low-calorie diet full of fruits and vegetables to lower your weight slowly but surely, can also be helpful.

If there is little or no change in cholesterol levels after three months of a healthy diet, routine exercise, and refraining from smoking, your doctor might want to try one of a number of cholesterol-lowering drugs. They include statins, niacin, bile acid resins, fibric acid derivatives and cholesterol absorption inhibitors:

statin drugs stop your liver from making cholesterol,
niacin is a vitamin that lowers LDL while raising HDL levels,
bile acid resins keep cholesterol from the liver from being reabsorbed by the intestines,
fibric acid derivatives can also increase your HDL levels.

Whatever medication is used, it should be in conjunction with a healthy diet and regular exercise. If your blood sugar levels rise after you commence on statin drugs, do not hesitate to talk to your doctor so he can prescribe a different cholesterol-lowering drug.

Conway Cover-Up: Media Ignores Admitted Obstruction Of Justice! – Alex Jones Tv 1/2 – [Conway Cover-Up: Media Ignores Admitted Obstruction Of Justice] Paul Joseph Watson & Kurt Nimmo www.infowars.com www.prisonplanet.tv October 27, 2010 While hyperventilating over the Lauren Valle stomping incident, the corporate media has ignored a far bigger scandal swirling around the Kentucky Senate race — the fact that financial contributors to Jack Conway’s campaign and Conway himself tipped off Conway’s brother to the fact that he was being investigated for trafficking drugs in an admitted obstruction of justice. The Kentucky Courier-Journal, which has favored Conway over Rand Paul in the course of the Senatorial race, hid the bombshell story behind a relatively tame headline this past weekend, presumably in a bid to protect Jack Conway from the blowback of the astounding revelations contained in the five page report written by RG Dunlop. The nitty gritty of the issue runs like this — Matthew C. Conway, prosecutor and brother of Jack Conway, the Democratic candidate for US Senator from Kentucky, was under investigation by the Louisville Metro Police for alleged drug use and drug trafficking. Two narcotics detectives involved in the case perverted the course of justice by tipping off Conway to the fact that he was under investigation. At least three narcotics officers are now under internal investigation for “policy violations”. After hearing detectives discussing the case in a restaurant, a Conway campaign supporter then also related the issue to Jack Conway, who …

From Twitter:

@jdhays21 go look where drug use per capita is higher… Eastern ky or Louisville. The entire city of Louisville funds the trash east of lex – by kborders14 (Kyle Borders)

From Twitter:

Long History of Drug Use in the Derby: By JIM SQUIRES LOUISVILLE, Ky. — By all accounts, the 90th Kentucky Derby… http://t.co/UcrQiuUp – by ARCpointLVL (ARCpoint Louisville)